The good news is that there's a pretty good capacity to move massive amounts of goods with very little human interaction.

The bad news is that there's a hell of a lot of human movement, and you'd have to shut down much of that, as well as isolate carriers and exposed individuals as quickly as possible. Often in places (such as the present African outbreak) in which infrastructure, governance, and resources are exceptionally limited. The task of effectively controling all vectors would be a very high challenge.

I'd say it would be an ugly time, all told.