at 60hz, an electro phoretic display (EPD) or eink will start to degrade very rapidly and consume more power than even a bright OLED panel will.
Eink is efficient only when you are NOT refreshing the screen constantly as it persists the last image drawn to screen, but if you wanna do any kind of scrolling, zooming etc, just use another kind of display tech.
E-Ink displays were declared having a lifespan of 10 million switches per dot: you would have to do a study about how often the average pixel is changed, but if that value were 5s, the lifespan would be "five years of short week 9-to-5" - that is not bad.
I am not sure if A2 mode or Greyscale Update with frequent dot switching is a stress that makes the dots degrade faster (not simply "decrease the life count going towards the max", but "decreasing the max"). I supposed not dramatically.
those switches per dot ratings are fair, but another assumption here is that EPD takes a non-0 amount of time to move the ink particles in the fluid they are suspended in with a magnetic field. when you try to move them more than roughly 8-12hz it already uses more power than a normal screen and if you run it at even higher voltages and speeds the ink particles start to burst and lose shape, leading to a greying out of the panel quite rapidly (within a few months)
Eink is efficient only when you are NOT refreshing the screen constantly as it persists the last image drawn to screen, but if you wanna do any kind of scrolling, zooming etc, just use another kind of display tech.