<audio> isn't meant for short, repetitive clips (which is what games do). There's a new API being built for this need, can't remember the name of it right now.
That's a rather absurd theory, considering that making the free online version work well on iOS would reduce Apple's income from a very, very popular iOS game.
I'm pretty sure FF4 supports everything that's needed to run a game like this, out of the box.